Related Experiment Video
Updated: Aug 1, 2026
15:57
Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
Vaccination studies against experimental bovine Pasteurella pneumonia
Summary
Pasteurella bacterins and vaccines were tested in calves for pneumonia prevention. Oil-adjuvanted Pasteurella haemolytica bacterins and live vaccines showed some efficacy, with effectiveness depending on vaccine dose.
Area of Science:
- Veterinary Immunology
- Bovine Respiratory Disease
Background:
- Pneumonic pasteurellosis is a significant challenge in cattle.
- Effective vaccines are crucial for preventing respiratory disease in calves.
Purpose of the Study:
- To evaluate the efficacy of different Pasteurella bacterins and vaccines against experimental pneumonic pasteurellosis in calves.
- To assess the impact of vaccine type, adjuvant, and dose on disease outcomes.
Main Methods:
- Colostrum-deprived calves were vaccinated with formalin-killed bacterins or live vaccines.
- Calves were challenge-exposed with Pasteurella haemolytica or Pasteurella multocida, with some pre-exposed to infectious bovine rhinotracheitis virus.
- Lesions, clinical signs, and hematological responses were evaluated post-challenge.
Main Results:
- Aluminum hydroxide-adsorbed bacterins showed limited efficacy, similar to control groups.
- An oil-adjuvanted P. haemolytica bacterin reduced clinical and pathological signs.
- A P. multocida oil-adjuvanted bacterin was not effective.
- Live Pasteurella vaccines reduced disease severity, with effectiveness appearing dose-dependent.
Conclusions:
- Oil-adjuvanted P. haemolytica bacterins and live Pasteurella vaccines offer potential protection against pneumonic pasteurellosis.
- Vaccine efficacy is influenced by formulation, adjuvant, and dosage.
- Further research into optimal vaccine strategies for Pasteurella infections is warranted.
