Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Non-continuous neuromodulation in awake, unrestrained felines increases bladder capacity.

Biomedical physics & engineering express·2026

Same author

Adaptive Pudendal Nerve Stimulation: A Pilot Study on Safety, Technical Feasibility, and Clinical Effect.

Neurourology and urodynamics·2026

Same author

Urethral Sensory Receptors in Voiding Physiology and Lower Urinary Tract Symptoms.

European urology focus·2026

Same author

Perioperative and clinical outcomes in patients undergoing Retzius-sparing robot assisted radical prostatectomy stratified by the degree of obesity.

International urology and nephrology·2026

Same author

Dr. Bob: A Forgotten Giant Amongst Proctologists.

Diseases of the colon and rectum·2026

Same author

Outcomes of Retzius-sparing robot-assisted radical prostatectomy in men aged ≥ 75 years.

BMC urology·2026

Same journal

How safe is teaching of highly specialized rectal surgery? A propensity score-matched 10-year cohort study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same journal

Minimally invasive repair of perineal hernia after abdominoperineal resection: A novel technique-A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same journal

Emergency minimally invasive colectomy: Approach or reconstructive strategy?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same journal

Prognostic impact of anal cancer morphology on survival and local recurrence: A 20-year regional cohort study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same journal

Rethinking lymphadenectomy in the immunotherapy era of colorectal cancer: A hypothesis-generating perspective.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same journal

Transanal minimally invasive surgery for rectal GIST-A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 7, 2025

Dorsal Column Steerability with Dual Parallel Leads using Dedicated Power Sources: A Computational Model

Dorsal Column Steerability with Dual Parallel Leads using Dedicated Power Sources: A Computational Model

Published on: February 10, 2011

The science behind programming algorithms for sacral neuromodulation.

Charles H Knowles¹, Stefan de Wachter², Stefan Engelberg³

¹Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Queen Mary University of London and Barts Health NHS Trust, London, UK.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland

|October 3, 2020

Summary

This summary is machine-generated.

Sacral neuromodulation (SNM) programming principles offer broad guidance but lack strong preclinical data support. Current clinical practice relies heavily on evolved experience rather than robust scientific evidence for optimizing SNM effectiveness.

Keywords:

Sacral nerve stimulation incontinence overactive bladder sacral neuromodulation

More Related Videos

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Published on: May 23, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Dec 7, 2025

Dorsal Column Steerability with Dual Parallel Leads using Dedicated Power Sources: A Computational Model

Dorsal Column Steerability with Dual Parallel Leads using Dedicated Power Sources: A Computational Model

Published on: February 10, 2011

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn

Published on: May 23, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Area of Science:

Neuroscience
Biomedical Engineering

Background:

Sacral neuromodulation (SNM) is a key treatment for overactive bladder, urinary retention, and fecal incontinence, offering sustained benefits.
Optimization of SNM effectiveness often requires adjustments in stimulation parameters like amplitude, frequency, and pulse width.
Existing recommendations for SNM programming are not always supported by comprehensive scientific data.

Purpose of the Study:

To review the scientific basis of stimulating mixed peripheral nerves relevant to SNM.
To examine available preclinical data supporting SNM parameter selection.
To provide clinicians with a theoretical basis for SNM programming.

Main Methods:

Narrative literature review focusing on the science of peripheral nerve stimulation and SNM preclinical data.
Analysis of electrode configuration, amplitude, frequency, pulse width, and cycling parameters.
Targeted review for clinicians interested in SNM, avoiding exhaustive basic neuroscience detail.

Main Results:

Neuromodulation science offers general principles for SNM programming, but these are broad.
Preclinical data do not strongly support specific clinical SNM parameters, even considering animal model limitations.
Theoretical programming principles are presented, acknowledging the significant role of clinical experience.

Conclusions:

Scientific understanding of neuromodulation provides a framework for SNM programming.
A gap exists between theoretical principles and strong preclinical evidence for specific clinical parameters.
Current SNM programming practices are a blend of scientific principles and accumulated clinical experience.