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Amoebae and humidifier fever.

M J Finnegan, C A Pickering, P S Davies

    Clinical Allergy
    |May 1, 1987
    PubMed
    Summary
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    Antibodies to amoebae were found in workers exposed to contaminated humidifiers. However, these antibodies did not correlate with humidifier fever (HF) or work-related asthma (WRA).

    Area of Science:

    • Environmental microbiology
    • Occupational health
    • Immunology

    Background:

    • Contaminated humidifiers can harbor microorganisms.
    • Exposure to contaminated humidifiers has been linked to respiratory illnesses.

    Purpose of the Study:

    • To investigate the presence of antibodies to Acanthamoeba polyphaga and Naegleria gruberi in workers exposed to contaminated humidifiers.
    • To determine if antibody presence correlates with humidifier fever (HF) or work-related asthma (WRA).

    Main Methods:

    • Sera from 119 workers at four work sites were tested using the immunofluorescent antibody (IFA) technique.
    • Amoebae were identified in humidifier samples.
    • Correlation analysis was performed with smoking habits, work-related symptoms, HF, and WRA.

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    Main Results:

    • Amoebae were detected in all studied humidifiers.
    • A positive IFA test correlated with precipitin reactions to humidifier antigen.
    • Antibody presence did not correlate with smoking, work-related symptoms, HF, or WRA.

    Conclusions:

    • Workers exposed to contaminated humidifiers show antibodies to specific amoebae.
    • The presence of these antibodies is not a reliable indicator for diagnosing humidifier fever or work-related asthma in this context.