Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Light and electronmicroscopic studies on Polycel ossicular replacement prostheses.

V C Cousins, K Jahnke

    Clinical Otolaryngology and Allied Sciences
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Building a Synthetic Cell Together.

    Nature communications·2025
    Same author

    HNO·2017
    Same author

    [Crew resource management and simulator training in acute stroke therapy].

    Der Nervenarzt·2016
    Same author

    [Obituary of Prof. Dr med. Klaus Jahnke].

    Laryngo- rhino- otologie·2016
    Same author

    Factors associated with symptom-specific psychological and functional impact among acoustic neuroma patients.

    The Journal of laryngology and otology·2013
    Same author

    Factors associated with anxiety and depression in the management of acoustic neuroma patients.

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2011
    Same journal

    Correspondence.

    Clinical otolaryngology and allied sciences·2017
    Same journal

    Erratum.

    Clinical otolaryngology and allied sciences·2013
    Same journal

    Compact training course in ear surgery erlangen, Germany, 26-28 february 1998.

    Clinical otolaryngology and allied sciences·2013
    Same journal

    How we do it: a practical approach to Foley catheter posterior nasal packing.

    Clinical otolaryngology and allied sciences·2004
    Same journal

    How we do it: management of tracheobronchial foreign bodies in children.

    Clinical otolaryngology and allied sciences·2004
    Same journal

    Is cochlear outer hair cell function affected by mobile telephone radiation?

    Clinical otolaryngology and allied sciences·2004
    See all related articles

    Polycel, a porous polyethylene for ossicular reconstruction, shows significant foreign body reactions and phagocytic consumption in gerbil middle ears. Further research is needed before human use.

    Area of Science:

    • Biomaterials Science
    • Otolaryngology
    • Tissue Engineering

    Background:

    • Porous high density polyethylene (Polycel) is a novel material proposed for ossicular chain reconstruction.
    • Limited data exists on the long-term tissue response and fate of Polycel in vivo.

    Purpose of the Study:

    • To evaluate the tissue tolerance and biological fate of Polycel implants in the middle ear.
    • To assess the suitability of Polycel for ossicular reconstruction based on tissue integration and reaction.

    Main Methods:

    • Polycel prostheses were implanted in the middle ear of gerbils.
    • Implants were retrieved at intervals between 1 and 5 months post-implantation.
    • Light and transmission electron microscopy were used to analyze tissue response and material degradation.

    Related Experiment Videos

    Main Results:

    • Polycel implants elicited a significant foreign body reaction.
    • Evidence of phagocytic activity and potential consumption of the material was observed.
    • Tissue integration patterns were similar to those seen with other porous plastics like Plastipore.

    Conclusions:

    • Polycel demonstrates a foreign body response comparable to existing porous plastics used in otology.
    • Concerns exist regarding the long-term biocompatibility and stability of Polycel due to phagocytic activity.
    • Reservations are raised about the extensive use of Polycel for ossicular reconstruction pending further investigation.