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Influence of Interferon Gamma +874 T>A (rs2430561) Polymorphism on Renal Allograft Rejection: A Meta-analysis
T Eiamsitrakoon1, P Tharabenjasin2, N Pabalan2
1Chulabhorn International College of Medicine, Thammasat University, Rangsit, Pathumthani, Thailand; Nephrology Unit, Faculty of Medicine, Thammasat University, Rangsit, Pathumthani, Thailand.
Background:
Reported associations of the interferon gamma (IFNG) +874T/A (rs2430561) polymorphism with post-kidney transplantation allograft rejection (AR) have been inconsistent, prompting a meta-analysis to obtain more precise estimates.
Methods:
Eighteen articles (22 studies) were included in the meta-analysis. Operating on the hypothesis that IFNG rs2430561 either increases or reduces AR risk, we used a genetic model-free approach to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Subgrouping was based on ethnicity (white, Middle Eastern, black, and mixed) and rejection type (ACR: acute rejection and CHR: chronic rejection). Quality of the associative effects was assessed with sensitivity treatment and test for publication bias.
Results:
The overall analysis in the dominant model indicated increased risk (OR = 1.26; Pa = .02) was validated in the ACR subgroup (OR = 1.29; Pa = .01), which contrasted with the CHR subgroup, with a nonsignificant effect indicating reduced risk (OR = 0.83; Pa = .68). Only the black subgroup showed significant increased risk (OR = 2.87; Pa = .04), but the association was tenuous on account of low sample size (n = 2) and imprecise effect (95% CI, 1.07-7.73).
Conclusions:
Increased risk associations (overall and ACR) of IFNG rs2430561 with AR is significant, robust, statistically powered, and lacking bias. Contrasting ACR (1.3-fold increased risk) and CHR (7% protective) effects may be clinically relevant in the genetics of renal transplantation.
