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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

Sadegh Fattahi1, Fatemeh Amjadi-Moheb2, Reza Tabaripour3

  • 1Student Research Committee, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; North Research Center, Pasteur Institute, Amol, Iran.

Life Sciences
|October 4, 2020
PubMed

Insights

The PI3K/AKT/mTOR pathway is crucial in gastric cancer, influencing progression and metastasis. Epigenetic changes and infections like H. pylori impact this pathway, offering therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • The PI3K/AKT/mTOR pathway regulates fundamental cellular processes.
  • Aberrant activation of this pathway is implicated in cancer development, chemoresistance, and metastasis.
  • Infections and epigenetic mechanisms can influence PI3K/AKT/mTOR signaling.

Purpose of the Study:

  • To review the role of the PI3K/AKT/mTOR pathway in gastric cancer.
  • To explore epigenetic alterations affecting this pathway in gastric cancer.
  • To discuss potential therapeutic strategies targeting this pathway.

Main Methods:

  • Literature review focusing on PI3K/AKT/mTOR signaling in gastric cancer.
  • Analysis of epigenetic modifications (DNA methylation, histone modifications, non-coding RNAs).
  • Inclusion of studies on infectious agents (H. pylori, Epstein-Barr virus) and their role.

Main Results:

  • The PI3K/AKT/mTOR pathway is a key driver in gastric cancer progression, metastasis, and chemoresistance.
  • Epigenetic alterations, including DNA methylation and non-coding RNAs, significantly modulate this pathway in gastric cancer.
  • Infections such as H. pylori and Epstein-Barr virus can dysregulate PI3K/AKT/mTOR signaling, impacting gastric cancer.

Conclusions:

  • The PI3K/AKT/mTOR pathway is a critical player in gastric cancer pathogenesis.
  • Epigenetic modifications and infections represent important regulatory mechanisms of this pathway in gastric cancer.
  • Targeting the PI3K/AKT/mTOR pathway offers promising therapeutic avenues for gastric cancer treatment.
Keywords:
ChemoresistanceEpigenetic modulationGastric cancerNon-coding RNAsPI3K/AKT/mTOR pathwayTargeted therapy

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