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Novel Oral Anticoagulants in Renal Transplant Recipients: A Retrospective Cohort Study

Nikolina Basic-Jukic1, Vesna Furic-Cunko1, Ivana Juric1

  • 1Department of nephrology, arterial hypertension, dialysis and transplantation, University hospital centre Zagreb, Faculty of medicine, University of Zagreb, Zagreb, Croatia.

Prilozi (Makedonska Akademija Na Naukite I Umetnostite. Oddelenie Za Medicinski Nauki)
|October 4, 2020
PubMed
Abstract

Insights

Novel anticoagulant drugs (NOACs) like rivaroxaban and apixaban show promise for safety and efficacy in renal transplant recipients, with stable graft function observed. Further research is recommended to confirm these findings.

Area of Science:

  • Nephrology
  • Pharmacology
  • Transplantation

Background:

  • Limited data exists on novel oral anticoagulants (NOACs) in renal transplant recipients.
  • Calcineurin inhibitor interactions and patient outcomes require further investigation.

Purpose of the Study:

  • To evaluate the safety and efficacy of NOACs in renal transplant recipients.
  • To assess adverse reactions, thromboembolic events, and drug interactions.

Main Methods:

  • Retrospective cohort study at a single center.
  • Analysis of 23 renal transplant recipients treated with NOACs (rivaroxaban, apixaban, dabigatran).
  • Assessment of bleeding, thrombosis, graft function, and hematological parameters.

Main Results:

  • Rivaroxaban and apixaban were associated with no thrombotic events and stable graft function over 24 months.
  • Two bleeding events occurred (one each with rivaroxaban and dabigatran).
  • Dabigatran was discontinued due to bleeding; rivaroxaban and apixaban showed favorable outcomes.

Conclusions:

  • Rivaroxaban and apixaban appear to be safe and effective anticoagulants in renal transplant patients.
  • Further studies are necessary to validate these findings and expand the evidence base.
Keywords:
apixabandabigatrannovel anticoagulant drugsrenal transplantationrivaroxaban

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