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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
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Thromboelastography findings in critically ill COVID-19 patients
Nouran Salem1, Bassam Atallah1,2, Wasim S El Nekidy1,2
1Department of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Journal of Thrombosis and Thrombolysis
|October 4, 2020
Summary
Critically ill COVID-19 patients show a lower incidence of hypercoagulable states, as measured by thromboelastography. This hypercoagulable state was not significantly linked to thrombotic events in these patients.
Area of Science:
- Critical Care Medicine
- Hematology
- Infectious Diseases
Background:
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with a high rate of thrombotic events.
- A hypercoagulable state, potentially induced by severe inflammation, is hypothesized to contribute to thrombosis in COVID-19 patients.
Discussion:
- This study investigated the incidence of hypercoagulable states using thromboelastography in critically ill COVID-19 patients.
- Thromboelastography parameters like maximum amplitude and a-angle were analyzed to identify hypercoagulability.
- The association between hypercoagulable states and thrombotic events was examined.
Key Insights:
- A hypercoagulable state was observed in 30.8% of critically ill COVID-19 patients.
- No significant association was found between the hypercoagulable state and the occurrence of thrombotic events (deep venous thrombosis, pulmonary embolism, arterial thrombosis).
- Inflammatory markers, coagulation markers, and thromboprophylaxis regimens did not correlate with the hypercoagulable state.
Outlook:
- Further research is needed to elucidate the complex mechanisms of thrombosis in COVID-19.
- Understanding the precise drivers of thrombotic events in COVID-19 may lead to improved patient management strategies.
- Investigating alternative diagnostic markers for hypercoagulability in COVID-19 patients could be beneficial.
Keywords:
COVID-19Critically ill patientsHypercoagulable stateThromboelastography (TEG)ThromboembolismThrombotic eventsMore Related Videos
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