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Procoagulant microparticles are associated with arterial disease in patients with systemic lupus erythematosus

Miguel Angel Plasín-Rodríguez1, Patricia Patricio1, Joan Monteagudo2

  • 1Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain.

Journal of Thrombosis and Thrombolysis
|October 4, 2020
PubMed

Insights

Microparticle (MP) procoagulant activity is higher in patients with systemic lupus erythematosus (SLE) who experience arterial thrombosis or have multiple carotid plaques. This finding highlights MPs as potential biomarkers for cardiovascular complications in SLE patients.

Area of Science:

  • Cardiovascular Science
  • Rheumatology
  • Hematology

Background:

  • Microparticles (MPs) are implicated in inflammatory and thrombotic diseases.
  • Elevated MP levels are observed in systemic lupus erythematosus (SLE) patients, correlating with cardiovascular disease.
  • The role of MP procoagulant activity in SLE-associated arteriosclerosis and arterial thrombosis requires further investigation.

Purpose of the Study:

  • To analyze the procoagulant activity of MPs in SLE patients.
  • To determine the correlation between MP procoagulant activity and subclinical arteriosclerosis (carotid plaques) and arterial thrombosis.
  • To assess the association of MP procoagulant activity with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL).

Main Methods:

  • Eighty-seven SLE patients were enrolled, categorized by APS and aPL status.
  • Subclinical arteriosclerosis was assessed using carotid artery ultrasonography.
  • MP procoagulant activity was measured via a functional assay utilizing annexin V.

Main Results:

  • Subclinical arteriosclerosis was detected in 21.8% of patients; 13 arterial and 8 venous thrombotic events were recorded.
  • MP procoagulant activity was significantly higher in patients with arterial thrombosis compared to those without.
  • Elevated MP procoagulant activity was associated with multiple carotid plaques (≥2) in patients without arterial thrombosis.
  • Multivariate analysis revealed MP procoagulant activity as an independent predictor of multiple carotid plaques and arterial thrombosis in SLE patients.

Conclusions:

  • The procoagulant activity of MPs is significantly associated with the burden of arteriosclerosis and the occurrence of arterial thrombosis in SLE patients.
  • MPs may serve as valuable biomarkers for identifying SLE patients at higher risk of cardiovascular events.
  • Further research is warranted to explore therapeutic strategies targeting MP-mediated procoagulation in SLE.
Keywords:
Arterial thrombosisArteriosclerosis burdenMicroparticlesProcoagulant activitySubclinical arteriosclerosisSystemic lupus erythematosus

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