Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres

James J Scanlon1, Stephen P Wren1

  • 1Department of Chemical & Pharmaceutical Sciences, Faculty of Science, Engineering & Computing, Kingston University London, Penryhn Road, Surrey, KT12EE, UK.

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Structure of Carboxylic Acid Derivatives
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The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
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