Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres
James J Scanlon1, Stephen P Wren1
1Department of Chemical & Pharmaceutical Sciences, Faculty of Science, Engineering & Computing, Kingston University London, Penryhn Road, Surrey, KT12EE, UK.
Abstract:
Aim: Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids. Materials & methods: Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated in silico. Results: The prepared compounds included the novel structure 4; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione. Conclusion: Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.
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