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Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Asthma-II: Pathophysiology and Classification01:26

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Chronic Obstructive Pulmonary Disease-V: Management01:29

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Asthma-Chronic Obstructive Pulmonary Disease Overlap.

Sunita Sharma1, Sandhya Khurana2, Alex D Federman3

  • 1Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, MS C272, Aurora, CO 80045-2563, USA.

Immunology and Allergy Clinics of North America
|October 5, 2020
PubMed
Summary
This summary is machine-generated.

Asthma-COPD overlap (ACO) affects patients with asthma or COPD. Further research is needed to clarify ACO

Keywords:
AsthmaAsthma-chronic obstructive pulmonary disease overlapChronic obstructive pulmonary diseaseDisease severity

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Area of Science:

  • Respiratory Medicine
  • Pulmonology
  • Clinical Science

Background:

  • Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) identifies patients with overlapping asthma and COPD characteristics.
  • ACO patients may present with persistent airflow obstruction (asthma) or variable airflow limitation with type 2 inflammation (COPD).

Purpose of the Study:

  • To review the clinical features, pathophysiology, and therapeutic options for Asthma-COPD overlap (ACO).
  • To highlight the need for further investigation into ACO as a distinct disorder.
  • To explore optimal management strategies for ACO patients compared to asthma or COPD alone.

Main Methods:

  • Literature review of clinical studies on ACO.
  • Analysis of current data on ACO pathophysiology.
  • Synthesis of information on therapeutic interventions for ACO.

Main Results:

  • ACO is characterized by a complex interplay of asthma and COPD features.
  • The underlying pathophysiology of ACO requires further elucidation.
  • Current therapeutic strategies for ACO are evolving.

Conclusions:

  • ACO represents a significant clinical phenotype requiring further research.
  • Distinguishing ACO may impact patient management and long-term outcomes.
  • Understanding ACO pathophysiology is crucial for developing targeted therapies.