Related Experiment Video
Updated: Dec 6, 2025
07:54
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
7.2K
Radiation Therapy for Malignant Pleural Mesothelioma
1Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, One Gustav L. Levy Place - Box 1236, New York, NY 10029, USA.
Thoracic Surgery Clinics
|October 5, 2020
Summary
Radiation therapy for malignant pleural mesothelioma is challenging. Newer techniques like pleural intensity-modulated radiation therapy (IMRT) are being explored after surgery to improve treatment effectiveness.
Area of Science:
- Oncology
- Radiation Oncology
- Thoracic Surgery
Background:
- Malignant pleural mesothelioma treatment presents significant technical challenges, particularly with radiation therapy.
- Historically, radiation therapy followed extrapleural pneumonectomy, yielding acceptable outcomes.
- The rise of pleurectomy/decortication has necessitated the development of advanced radiation techniques.
Purpose of the Study:
- To review the evolution and current status of radiation therapy techniques for malignant pleural mesothelioma.
- To highlight the introduction and growing experience with pleural intensity-modulated radiation therapy (IMRT).
- To discuss ongoing clinical trials evaluating IMRT's effectiveness in different surgical contexts.
Main Methods:
- Review of historical and current radiation therapy approaches for malignant pleural mesothelioma.
- Introduction of intensity-modulated radiation therapy (IMRT) as an advanced technique.
- Mention of ongoing clinical trials assessing IMRT efficacy.
Main Results:
- Radiation therapy for malignant pleural mesothelioma remains technically demanding.
- Intensity-modulated radiation therapy (IMRT) has emerged as a key advancement.
- Multiple trials are underway to determine the effectiveness of IMRT post-surgery.
Conclusions:
- Advancements in radiation therapy, such as IMRT, are crucial for improving malignant pleural mesothelioma treatment.
- Ongoing research and clinical trials are essential to validate the effectiveness of these new techniques.
- The integration of IMRT with surgical procedures like extrapleural pneumonectomy and pleurectomy/decortication shows promise.
Related Concept Videos
01:30Pleural Disorders: Types and Brief Description
474
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
474
01:28Pleural Effusion II: Symptoms and Management
452
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
452
01:27Pneumothorax-II
685
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
685