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[Evaluation of drug interactions in patients treated for a lung or digestive cancer]

Vincent Ghysel1, Emmanuelle Tresch2, Guillaume Marliot3

  • 1Centre Oscar-Lambret, CISSPO, 3, rue Combemale, 59020 Lille, France.

Bulletin Du Cancer
|October 5, 2020
PubMed
Abstract

Insights

Cancer patients frequently experience drug interactions, with 75% of patients in this study affected. Polypharmacy (using 3+ drugs) significantly increased this risk, highlighting the need for collaboration to prevent adverse events.

Area of Science:

  • Oncology
  • Clinical Pharmacy
  • Pharmacovigilance

Background:

  • Cancer patients face elevated risks of drug interactions.
  • Limited in-depth studies on drug interaction risks in French oncology settings.
  • Need for comprehensive analysis of drug interactions in lung and digestive cancer patients.

Purpose of the Study:

  • To determine the prevalence of drug interactions in hospitalized lung and digestive cancer patients in France.
  • To identify risk factors associated with drug interactions in this population.
  • To highlight specific anticancer drugs involved in contraindicated or not recommended combinations.

Main Methods:

  • Analysis of drug prescriptions for 93 oncology patients between May 27, 2019, and July 7, 2019.
  • Utilized two software programs, Thériaque™ and DDI Predictor™, for drug interaction identification.
  • Included 88 patients in the final analysis.

Main Results:

  • 544 drug interactions identified in 66 out of 88 patients (75.0%).
  • 22.7% of patients had non-recommended or contraindicated drug combinations.
  • Etoposide was the most frequently implicated anticancer drug; polypharmacy (≥3 drugs) was a significant risk factor (83% vs. 23%).

Conclusions:

  • Drug interactions are a significant concern for hospitalized cancer patients.
  • Strengthening collaboration between physicians and pharmacists is crucial for prevention.
  • Ongoing monitoring and intervention strategies are necessary to mitigate risks.
Keywords:
Anticancer chemotherapyChimiothérapie anticancéreuseDrug interactionInteraction médicamenteusePolymédicationPolypharmacyToxicityToxicité

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