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Updated: Dec 6, 2025

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
Toxoplasma gondii: AnUnderestimated Threat?
Gregory Milne1, Joanne P Webster1, Martin Walker1
1Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, UK; London Centre for Neglected Tropical Disease Research, School of Public Health, Imperial College London, London, UK.
Latent Toxoplasma gondii infection, not just congenital toxoplasmosis, is linked to neuropsychiatric disorders. This parasite
Area of Science:
- Neuroscience
- Infectious Diseases
- Public Health
Background:
- Toxoplasma gondii traditionally viewed as a public health concern for congenital toxoplasmosis and immunocompromised individuals.
- Emerging evidence links latent T. gondii infection to a spectrum of neuropsychiatric disorders.
Purpose of the Study:
- To present assimilated evidence on T. gondii associations with human neuropsychiatric disorders.
- To outline a unifying causal framework for these epidemiological associations.
Main Methods:
- Review and assimilation of existing epidemiological and scientific evidence.
- Development of a theoretical causal framework to explain observed associations.
Main Results:
- Significant associations found between T. gondii infection and various neuropsychiatric conditions.
- Latent T. gondii infection's subtle, widespread effects may surpass overt toxoplasmosis morbidity.
Conclusions:
- The public health impact of T. gondii, particularly latent infections, is likely underestimated.
- Re-evaluation of T. gondii's public health importance is warranted, considering its neuropsychiatric implications.
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