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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Updated: Dec 6, 2025

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Glomerular Diseases with Reference to COVID-19.

Sanjeev Gulati1, Narayan Prasad2, Manisha Sahay3

  • 1Nephrology and Kidney Transplant Fortis Gp of Hospitals, New Delhi, India.

Indian Journal of Nephrology
|October 5, 2020
PubMed
Summary
This summary is machine-generated.

Patients with glomerular disease on immunosuppression face higher COVID-19 risks. This study developed guidelines to adjust treatments, balancing disease control with minimizing infection risk.

Keywords:
Immunosuppressionprimary glomerular diseasesecondary glomerular diseases

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Area of Science:

  • Nephrology
  • Immunology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic poses significant risks to immunocompromised individuals.
  • Patients with primary or secondary glomerular diseases often require moderate to high doses of immunosuppressive therapy.
  • A clear understanding of COVID-19 risk relative to immunosuppression dosage and duration is lacking.

Purpose of the Study:

  • To develop a clinical guideline for modifying immunosuppressive treatment regimens in patients with glomerular diseases.
  • To help clinicians balance the risk of disease relapse or flare against the risk of COVID-19 infection.
  • To provide evidence-based recommendations for managing immunosuppression during the pandemic.

Main Methods:

  • Literature review on immunosuppression and COVID-19 in glomerular disease patients.
  • Expert consensus on drug modification strategies.
  • Risk-benefit analysis of treatment adjustments.

Main Results:

  • Identification of specific immunosuppressive drugs and their associated COVID-19 risks.
  • Recommendations for dose reduction or temporary cessation of certain agents.
  • Strategies for monitoring disease activity and infection status.

Conclusions:

  • Careful modification of immunosuppressive therapy is crucial for patients with glomerular diseases during the COVID-19 pandemic.
  • Guidelines can aid clinicians in optimizing patient management.
  • Further research is needed to refine risk stratification and treatment protocols.