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Rare, Yet Emerging Cause of Graft Dysfunction-ALECT 2 Amyloidosis.

Kulwant Singh¹, Jasmine Sethi¹, Rajan Duggal²

¹Division of Nephrology, Grecian Hospital, Mohali, Punjab, India.

Indian Journal of Nephrology

|October 5, 2020

Summary

Leukocyte cell-derived chemotaxin 2 (LECT2) amyloidosis is a rare condition affecting kidneys and liver. This case highlights a LECT2 renal amyloidosis in a transplant recipient, emphasizing the need for further research into effective therapies.

Keywords:

ALECT2 amyloid graft dysfunction renal transplant

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Area of Science:

Nephrology
Pathology
Transplantation

Background:

Amyloidosis involves abnormal protein aggregate deposition, with AL protein being most common.
Leukocyte cell-derived chemotaxin 2 (LECT2) amyloidosis is a recently identified subtype, primarily affecting the kidneys and liver.
This condition lacks established effective therapeutic strategies.

Observation:

A kidney transplant recipient presented with declining graft function and proteinuria.
Diagnostic evaluation revealed amyloid deposition consistent with LECT2 amyloidosis in the kidney graft.
This represents the first documented case of LECT2 amyloidosis in a transplant recipient from Northern India.

Findings:

The case confirms ALECT2 amyloidosis can affect kidney allografts.
The clinical presentation included progressive graft dysfunction and subnephrotic proteinuria.
No specific therapeutic interventions for ALECT2 amyloidosis are currently established.

Implications:

This case expands the known clinical spectrum and geographic distribution of ALECT2 amyloidosis.
Understanding ALECT2 amyloidosis in transplant recipients is crucial for graft surveillance and management.
Further research is needed to develop targeted therapies for this rare amyloidosis subtype.