Local Protocol for Management of Low-Grade Appendiceal Mucinous Neoplasm (LAMN)

Area of Science:

• Gastroenterology
• Surgical Oncology
• Pathology

Background:

• Management and surveillance of low-grade appendiceal mucinous neoplasm (LAMN) present challenges in colorectal multidisciplinary decision-making.
• Establishing a standardized local protocol is crucial for consistent patient care.

Purpose of the Study:

• To develop a local management and surveillance protocol for low-grade appendiceal mucinous neoplasm (LAMN).
• To analyze outcomes of LAMN patients treated with appendicectomy.

Main Methods:

• Retrospective analysis of patients diagnosed with LAMN post-appendicectomy from 2011-2017.
• Review of operative notes, investigations, follow-up data, and development of pseudomyxoma peritonei (PMP).

Main Results:

• 36 patients diagnosed with LAMN out of 4,628 appendicectomies.
• No patients developed pseudomyxoma peritonei (PMP) or required further surgery related to LAMN.
• Varied follow-up modalities including CT scans, USS, and colonoscopies were utilized.

Conclusions:

• The study supports appendicectomy as a primary treatment for LAMN.
• A defined protocol can aid in the effective management and surveillance of LAMN.
• Long-term follow-up data indicates a low risk of PMP development after appendicectomy for LAMN.