Temporal Variability in Electrocardiographic Indices in Subjects With Brugada Patterns
Sharen Lee1, Jiandong Zhou2, Tong Liu3
1Laboratory of Cardiovascular Physiology, Li Ka Shing Institute of Health Sciences, Hong Kong, China.
Frontiers in Physiology
|October 5, 2020
Summary
Temporal variations in electrocardiogram (ECG) markers like JTp and ST elevation can help identify patients with Brugada pattern at higher risk for arrhythmias. This aids in better risk stratification for these individuals.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Diagnostics
Background:
- Brugada electrocardiographic (ECG) patterns are associated with varying levels of arrhythmic risk.
- Risk stratification in these patients is crucial for timely intervention.
- Temporal variations in ECG markers may offer additional prognostic information.
Purpose of the Study:
- To evaluate the relationship between temporal variability of ECG markers and arrhythmic outcomes in patients with Brugada pattern.
- To compare ECG marker variability between low-risk asymptomatic subjects and high-risk symptomatic patients (syncope, VT/VF).
Main Methods:
- Analysis of serial ECGs and electronic health records from 81 patients with Brugada patterns.
- Assessment of temporal variability (standard deviation, max-min difference) of QRS interval, JTp, Tp-e, ST elevation (V1-3), and RR-interval (lead II).
Main Results:
- Patients with type 1 Brugada ECG pattern showed higher JTp variability (lead V2) and ST elevation variability (lead V1).
- Significantly greater Tp-e interval variability (lead V3) was observed in the ventricular tachycardia/ventricular fibrillation (VT/VF) group compared to syncope and asymptomatic groups.
Conclusions:
- Temporal variability in specific ECG indices (JTp, ST elevation, Tp-e) may enhance risk stratification in patients with Brugada pattern.
- These findings suggest a potential role for dynamic ECG analysis in managing Brugada syndrome.
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