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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Circulating MicroRNAs: Biogenesis and Clinical Significance in Acute Myocardial Infarction
Lei Zhang1, Han Ding1, Yuan Zhang1
1Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Abstract:
Acute myocardial infarction (AMI) causes many deaths around the world. Early diagnosis can prevent the development of AMI and provide theoretical support for the subsequent treatment. miRNAs participate in the AMI pathological processes. We aim to determine the early diagnostic and the prognostic roles of circulating miRNAs in AMI in the existing studies and summarize all the data to provide a greater understanding of their utility for clinical application. We reviewed current knowledge focused on the AMI development and circulating miRNA formation. Meanwhile, we collected and analyzed the potential roles of circulating miRNAs in AMI diagnosis, prognosis and therapeutic strategies. Additionally, we elaborated on the challenges and clinical perspectives of the application of circulating miRNAs in AMI diagnosis. Circulating miRNAs are stable in the circulation and have earlier increases of circulating levels than diagnostic golden criteria. In addition, they are tissue and disease-specific. All these characteristics indicate that circulating miRNAs are promising biomarkers for the early diagnosis of AMI. Although there are several limitations to be resolved before clinical use, the application of circulating miRNAs shows great potential in the early diagnosis and the prognosis of AMI.
Insights
Circulating microRNAs (miRNAs) show promise as early diagnostic biomarkers for acute myocardial infarction (AMI). These stable molecules offer potential for improved AMI diagnosis and prognosis, aiding clinical decisions.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Acute myocardial infarction (AMI) is a leading cause of global mortality.
- Early diagnosis of AMI is crucial for effective treatment and improved patient outcomes.
- MicroRNAs (miRNAs) are implicated in the pathological processes of AMI.
Purpose of the Study:
- To evaluate the diagnostic and prognostic roles of circulating miRNAs in AMI.
- To synthesize existing data on circulating miRNAs for clinical application in AMI.
- To explore the potential of circulating miRNAs as early diagnostic biomarkers for AMI.
Main Methods:
- Systematic review of current knowledge on AMI development and circulating miRNA formation.
- Analysis of potential roles of circulating miRNAs in AMI diagnosis, prognosis, and therapy.
- Discussion of challenges and clinical perspectives for circulating miRNA application in AMI diagnosis.
Main Results:
- Circulating miRNAs are stable in bodily fluids and exhibit early elevation compared to traditional diagnostic markers.
- miRNAs demonstrate tissue and disease specificity, enhancing their potential as biomarkers.
- Existing studies suggest circulating miRNAs are promising for early AMI diagnosis and prognosis.
Conclusions:
- Circulating miRNAs possess characteristics suitable for early AMI diagnosis.
- Despite current limitations, circulating miRNAs hold significant potential for clinical application in AMI.
- Further research is needed to overcome challenges before widespread clinical adoption for AMI management.
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