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Updated: Dec 6, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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PCSK9 Monoclonal Antibodies: An Overview

Rasha Kaddoura1, Bassant Orabi1, Amar M Salam2

  • 1Pharmacy Department, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.

Heart Views : the Official Journal of the Gulf Heart Association
|October 5, 2020
PubMed
Summary

PCSK9 monoclonal antibodies effectively lower LDL cholesterol in hypercholesterolemia patients. These novel therapies reduce cardiovascular events but not mortality, with a favorable safety profile.

Keywords:
Alirocumabantidrug antibodybococizumabcardiovascular diseasesevolocumabfamilial hypercholesterolemianeurocognitiveproprotein convertase subtilisin-kexin type 9 inhibitors

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