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Updated: Dec 6, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
Ornella I Selmin1,2, Micah G Donovan2, Barbara J Stillwater3
1Department of Nutritional Sciences, The University of Arizona, Tucson, AZ, United States.
None:
Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.
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