Related Experiment Video

Updated: Dec 6, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.8K

Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Ornella I Selmin1,2, Micah G Donovan2, Barbara J Stillwater3

  • 1Department of Nutritional Sciences, The University of Arizona, Tucson, AZ, United States.

Frontiers in Nutrition
|October 5, 2020
PubMed

Insights

Triple negative breast cancer (TNBC) is aggressive and hard to treat. This review explores how diet impacts epigenetic changes in TNBC, offering potential new management strategies.

Area of Science:

  • Oncology
  • Epigenetics
  • Nutritional Science

Background:

  • Triple negative breast cancer (TNBC) is a heterogeneous cancer subtype lacking ER, PR, and HER2 expression.
  • TNBC is associated with high mutation rates, metastasis, and poor patient survival outcomes.
  • Epigenetic dysregulation plays a critical role in TNBC pathogenesis.

Purpose of the Study:

  • To review epigenetic mechanisms driving TNBC.
  • To highlight the influence of dietary components on TNBC epigenetics.
  • To explore dietary strategies for TNBC management.

Main Methods:

  • Literature review of epigenetic regulation in TNBC.
  • Analysis of studies on dietary factors and cancer epigenetics.
  • Synthesis of findings on food components affecting TNBC pathways.

Main Results:

  • Epigenetic alterations are key drivers of TNBC heterogeneity and progression.
  • Specific dietary components can modulate epigenetic marks relevant to TNBC.
  • Dietary interventions show promise in influencing TNBC development and spread.

Conclusions:

  • Epigenetic mechanisms are crucial in TNBC.
  • Dietary food components offer a modifiable target for TNBC management.
  • Further research into nutritional epigenetics can lead to novel therapeutic strategies for TNBC.
Keywords:
DNA methylationdietary bioactive compoundsepigenetic regulationtriple negative breast cancertumor suppressor

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.6K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.9K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.0K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
37.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K