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Clinical Significance of CD147 in Children with Inflammatory Bowel Disease
Hongli Wang1,2, Jun Ye3, Ruitao Liu2
1The First Affiliated Hospital, Jinan University, Guangzhou, China.
Insights
Increased CD147 levels indicate a potential biomarker for pediatric inflammatory bowel disease (IBD). This transmembrane glycoprotein plays a role in intestinal inflammation and barrier function, distinguishing active IBD from inactive disease and healthy controls.
Area of Science:
- Immunology
- Gastroenterology
- Molecular Biology
Background:
- CD147/basigin (Bsg) is a transmembrane glycoprotein known to activate matrix metalloproteinases and promote inflammation.
- Its role in the pathogenesis of inflammatory bowel disease (IBD) requires further clinical investigation.
Purpose of the Study:
- To explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD).
- To evaluate CD147 as a potential diagnostic biomarker for IBD.
Main Methods:
- Clinical analysis of leukocyte subsets in IBD patients versus controls.
- Immunohistochemistry to assess CD147 expression in intestinal tissues.
- In vitro studies using HT-29 and CaCO2 cells to investigate CD147's effect on MCT4 expression.
- Serum level measurements of CD147 in active IBD, inactive IBD, and healthy controls.
Main Results:
- CD147 expression was significantly increased in the intestinal tissue of patients with active IBD compared to controls.
- CD147 influences MCT4 expression, impacting intestinal barrier function and inflammation in cell models.
- Serum CD147 levels were higher in active IBD patients than in inactive IBD or healthy individuals, suggesting its potential as a biomarker.
Conclusions:
- Elevated CD147 levels in the serum and intestinal tissue are associated with active IBD.
- CD147 may serve as a valuable biomarker for diagnosing and monitoring IBD, particularly in pediatric populations.
Background:
CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation.
Objective:
The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD).
Results:
In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147 was increased in intestinal tissue of patients with active IBD compared to that in the control group. What is more, CD147 is involved in intestinal barrier function and intestinal inflammation, which was attributed to the fact that it has an influence on MCT4 expression, a regulator of intestinal barrier function and intestinal inflammation, in HT-29 and CaCO2 cells. Most importantly, serum level of CD147 content is higher in active IBD than that in inactive IBD or healthy control, which could be a biomarker of IBD.
Conclusion:
The data suggested that increased CD147 level could be a biomarker of IBD in children.
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