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Cardiac Endocrinology: Heart-Derived Hormones in Physiology and Disease

Juanjuan Zhao1, Liming Pei1,2

  • 1Center for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

JACC. Basic to Translational Science
|October 5, 2020
PubMed

Insights

The heart produces hormones that regulate bodily functions and communicate with distant organs. This review explores heart-derived hormones, their mechanisms, and clinical significance in cardiac endocrinology.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • The heart is a central organ in the circulatory system, supplying oxygen and nutrients.
  • The heart synthesizes and secretes endocrine signals to communicate with target organs.
  • Heart-derived hormones play a crucial role in coordinating cardiac function and systemic biology.

Purpose of the Study:

  • To review the biochemistry, signaling, function, regulation, and clinical significance of heart-derived hormones.
  • To focus on the cardiovascular system's role in cardiac endocrinology.
  • To identify key questions for advancing the field of cardiac endocrinology.

Main Methods:

  • Literature review of existing studies on heart-derived hormones.
  • Analysis of biochemical and signaling pathways.
  • Examination of clinical significance and regulatory mechanisms.

Main Results:

  • Heart-derived hormones share a unified mechanism in coordinating cardiac and target organ functions.
  • Representative heart-derived hormones have significant roles in the cardiovascular system.
  • The review synthesizes current knowledge on cardiac endocrinology.

Conclusions:

  • Heart-derived hormones are critical endocrine signals with broad physiological impacts.
  • Understanding these hormones is vital for advancing cardiovascular medicine.
  • Further research is needed to address key questions in cardiac endocrinology.

Keywords:
ANP, atrial natriuretic peptideActR, activin receptorBNP, brain natriuretic peptideCNP, C-type natriuretic peptideFGF, fibroblast growth factorFSTL, follistatin-likeGDF, growth differentiation factorGDF15GFRAL, GDNF family receptor α-likeNPR, natriuretic peptide receptorsPCSK, proprotein convertase subtilisin/kexin typeST2, suppression of tumorigenesis-2TGF, transforming growth factorcardiac endocrinologyheartheart-derived hormones

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