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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
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Maternal vaccinations.

Khai Lin Kong1, Sushena Krishnaswamy2, Michelle L Giles3

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Australian Journal of General Practice
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Maternal immunisation during pregnancy protects mothers and infants from serious diseases. Expanding vaccine options, including for travel and new threats like RSV, enhance maternal and neonatal health.

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Area of Science:

  • Immunology
  • Public Health
  • Obstetrics

Background:

  • Maternal immunisation involves vaccinations during pregnancy for maternal and infant health.
  • The field is expanding with new vaccines currently in development.
  • It is a key component of preventive healthcare for pregnant individuals and newborns.

Purpose of the Study:

  • To review the principles and recommendations for maternal immunisation.
  • To discuss maternal vaccines in development, including those for travel.
  • To examine safety data for inadvertent live vaccine administration during pregnancy.

Main Methods:

  • Literature review of existing recommendations and safety data.
  • Analysis of principles underpinning maternal immunisation strategies.
  • Examination of vaccines in development for maternal and neonatal use.

Main Results:

  • Maternal immunisation protects against severe maternal diseases like influenza.
  • It significantly reduces infant morbidity and mortality, as seen with pertussis vaccines.
  • New vaccines targeting RSV and Group B Streptococcus show promise for improving maternal and neonatal outcomes.

Conclusions:

  • Maternal immunisation is crucial for enhancing maternal and neonatal health.
  • The development of new maternal vaccines broadens the scope of protection.
  • Continued research and implementation are vital for maximizing public health benefits.