Related Experiment Video
Updated: Dec 6, 2025

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
Published on: April 7, 2023
Role of a Pediatric Cardiologist in the COVID-19 Pandemic
Talha Niaz1, Kyle Hope2, Michael Fremed3
1Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Insights
Children with COVID-19 can develop multisystem inflammatory syndrome (MIS-C), presenting distinct gastrointestinal and shock-like symptoms. Cardiovascular involvement, including myocardial dysfunction and coronary artery issues, is a significant concern in these pediatric cases.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Coronavirus disease 2019 (COVID-19) impacts all ages, with varying severity.
- While younger individuals generally experience milder COVID-19, a severe multisystem inflammatory syndrome in children (MIS-C) has emerged.
- MIS-C shares features with Kawasaki disease but presents unique gastrointestinal and shock-like symptoms.
Purpose of the Study:
- To review current literature on cardiovascular involvement in pediatric COVID-19 and MIS-C.
- To summarize the understanding of cardiac manifestations in children affected by COVID-19 or MIS-C.
- To define the role of pediatric cardiologists in managing these complex cases.
Main Methods:
- Literature review of studies on pediatric COVID-19 and MIS-C.
- Synthesis of findings regarding cardiovascular complications.
- Analysis of clinical presentations and management strategies.
Main Results:
- Children with MIS-C frequently exhibit severe gastrointestinal symptoms and shock.
- Significant cardiovascular involvement is observed, including myocardial dysfunction, valvulitis, and coronary artery aneurysms.
- Distinct differences exist between MIS-C and typical Kawasaki disease presentations.
Conclusions:
- Cardiovascular complications are a critical aspect of MIS-C in children.
- Pediatric cardiologists play a vital role in the diagnosis and management of these patients.
- Further research is needed to fully understand and treat cardiac sequelae of COVID-19 in children.
Abstract:
Coronavirus disease 2019 (COVID-19) has affected patients across all age groups, with a wide range of illness severity from asymptomatic carriers to severe multi-organ dysfunction and death. Although early reports have shown that younger age groups experience less severe disease than older adults, our understanding of this phenomenon is in continuous evolution. Recently, a severe multisystem inflammatory syndrome in children (MIS-C), with active or recent COVID-19 infection, has been increasingly reported. Children with MIS-C may demonstrate signs and symptoms of Kawasaki disease, but also have some distinct differences. These children have more frequent and severe gastrointestinal symptoms and are more likely to present with a shock-like presentation. Moreover, they often present with cardiovascular involvement including myocardial dysfunction, valvulitis, and coronary artery dilation or aneurysms. Here, we present a review of the literature and summary of our current understanding of cardiovascular involvement in children with COVID-19 or MIS-C and identifying the role of a pediatric cardiologist in caring for these patients.
More Related Videos
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Cardiopulmonary Resuscitation I: Adult
Introduction Cardiac Emergencies
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiopulmonary Resuscitation III: AED Use
Pharmacokinetics in Pediatric Patients: Drug Excretion

