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MiR-30 suppresses lung cancer cell 95D epithelial mesenchymal transition and invasion through targeted regulating

M-J Fan1, Y-H Zhong, W Shen

  • 1Department of Respiratory Medicine, The Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China.

European Review for Medical and Pharmacological Sciences
|October 5, 2020
PubMed

Insights

This study on miR-30 and lung cancer was withdrawn due to suspected research misconduct. The authors did not provide evidence of data originality, leading to the article

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Lung cancer is a leading cause of cancer mortality.
  • MicroRNAs (miRNAs) play crucial roles in cancer development.
  • Epithelial-mesenchymal transition (EMT) is a key process in cancer invasion and metastasis.

Purpose of the Study:

  • To investigate the role of miR-30 in suppressing lung cancer cell EMT and invasion.
  • To identify the molecular targets of miR-30 in lung cancer.

Main Methods:

  • The study utilized lung cancer cell lines (95D).
  • It examined the effect of miR-30 on EMT and invasion.
  • Target regulation by miR-30 was investigated, focusing on the Snail pathway.

Main Results:

  • MiR-30 was found to suppress EMT and invasion in 95D lung cancer cells.
  • miR-30 was shown to target and regulate Snail.

Conclusions:

  • miR-30 acts as a tumor suppressor in lung cancer by inhibiting EMT and invasion.
  • Targeting the miR-30/Snail axis may offer a therapeutic strategy for lung cancer.

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