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MiR-16 inhibits pituitary adenoma cell proliferation via the suppression of ERK/MAPK signal pathway

D-W Wang1, Y-Q Wang, H-S Shu

  • 1Department of Neurosurgery, the Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, People's Republic of China.

European Review for Medical and Pharmacological Sciences
|October 5, 2020
PubMed

Insights

This study on MiR-16 and pituitary adenoma cell proliferation has been withdrawn due to suspected research misconduct. The publisher retracted the article as authors did not prove data originality.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Pituitary adenomas are common tumors affecting hormone regulation.
  • MicroRNAs (miRNAs) play roles in tumor development.
  • The ERK/MAPK pathway is implicated in cell proliferation.

Purpose of the Study:

  • To investigate the role of MiR-16 in pituitary adenoma cell proliferation.
  • To explore the potential involvement of the ERK/MAPK signaling pathway.

Main Methods:

  • The study aimed to analyze MiR-16 expression in pituitary adenoma cells.
  • Investigated the effect of MiR-16 on cell proliferation.
  • Examined the impact on the ERK/MAPK signaling pathway.

Main Results:

  • The article reported that MiR-16 inhibited pituitary adenoma cell proliferation.
  • The proposed mechanism involved the suppression of the ERK/MAPK signal pathway.

Conclusions:

  • The findings suggested MiR-16 as a potential therapeutic target.
  • MiR-16's role in suppressing the ERK/MAPK pathway was highlighted.

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