SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks.

Area of Science:

• Ophthalmology
• Virology
• Public Health

Background:

• The COVID-19 pandemic raised concerns about SARS-CoV-2 transmission via tissue transplantation.
• Debate existed regarding the safety of tissue banking processes during the pandemic.

Purpose of the Study:

• To analyze the impact of SARS-CoV-2 on corneal donor tissue harvesting and eye bank operations in Germany.
• To understand the adaptations made by German eye banks in response to the pandemic.

Main Methods:

• A questionnaire was distributed to 26 eye banks in Germany.
• The survey focused on changes in donor screening and corneal tissue harvesting post-SARS-CoV-2 emergence.
• Data on recruitment, testing, protective measures, and tissue yield were collected.

Main Results:

• Eighteen eye banks reduced donor recruitment, and two ceased operations.
• Additional screening (conjunctival/nasopharyngeal swabs) was adopted by eight banks.
• A mean reduction of 17% in obtained donor tissues was observed across participating banks.

Conclusions:

• New screening protocols and protective measures for corneal donation during the COVID-19 pandemic led to a significant decrease in tissue availability.
• Limited adoption of advanced diagnostic tests may stem from concerns about sensitivity and validation for postmortem use.
• Future guideline revisions are anticipated as research clarifies SARS-CoV-2 risks in cornea donation, balancing safety with the persistent demand for donor corneas.