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Comparative Pathology of the Peripheral Nervous System.
Lisa G Lanigan1, Duncan S Russell2, Kevin D Woolard3
1StageBio, Inc, Frederick, MD, USA.
Veterinary Pathology
|October 5, 2020
Summary
Peripheral nervous system (PNS) diseases are often overlooked. This review details PNS anatomy, physiology, sampling, and common lesions for pathologists, aiding in comparative pathology practice.
Area of Science:
- Neuroscience
- Pathology
- Comparative Medicine
Background:
- The peripheral nervous system (PNS) is crucial for transmitting signals between the central nervous system and the body.
- PNS diseases are frequently underdiagnosed in diagnostic and experimental pathology.
- A comprehensive understanding of PNS neuroanatomy and physiology is essential for accurate disease evaluation.
Purpose of the Study:
- To provide a detailed overview of peripheral nervous system (PNS) neuroanatomy and physiology.
- To outline appropriate PNS sampling and processing techniques for pathological examination.
- To review major classes of PNS lesions and categories of PNS diseases.
Main Methods:
- Literature review focusing on PNS neuroanatomy, physiology, and pathology.
- Categorization of PNS lesions into neuronopathy, axonopathy, and myelinopathy.
- Discussion of various PNS disease categories, including toxic, metabolic, infectious, inflammatory, and neoplastic conditions.
Main Results:
- Key features of somatic and autonomic PNS neuroanatomy and physiology are highlighted.
- Common PNS lesions, such as neuronopathies, axonopathies, and myelinopathies, are described.
- Diagnostic criteria for a broad range of common PNS lesions are presented.
Conclusions:
- This review serves as a valuable resource for pathologists evaluating PNS diseases.
- It emphasizes the importance of appropriate PNS sampling and processing techniques.
- Provides essential references for pathologists in comparative pathology practice.
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