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A two-component charge transfer hydrogel with excellent sensitivity towards the microenvironment: a responsive
Dipen Biswakarma1, Nilanjan Dey, Santanu Bhattacharya
1Department of Organic Chemistry, Indian Institute of Science, Bangalore, Karnataka 560012, India. sb@iisc.ac.in.
Soft Matter
|October 5, 2020
Summary
This study developed a novel charge transfer (CT) hydrogel from pyrene and NBD-Ox derivatives. The hydrogel can discriminate biogenic thiols like cysteine and glutathione through distinct fluorescence responses.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Analytical Chemistry
Background:
- Hydrogels are versatile materials with tunable properties.
- Charge transfer (CT) interactions can form novel supramolecular assemblies.
- Sensing of biogenic thiols is crucial for diagnostics.
Purpose of the Study:
- To synthesize a two-component charge transfer (CT) hydrogel.
- To investigate the hydrogel's structural, mechanical, and responsive properties.
- To explore the CT hydrogel's application in discriminating biogenic thiols.
Main Methods:
- Supramolecular heteroassembly of pyrene amino acid conjugate (donor) and NBD-Ox derivative (acceptor).
- Characterization using circular dichroism, morphology studies, XRD, and rheological measurements.
- Development of a turn-on fluorescence sensing assay for biogenic thiols.
Main Results:
- Formation of a CT hydrogel with tunable mechanical stiffness and thermal stability.
- Evidence of left-handed helical fibers and lamellar packing in the 3D network.
- Successful discrimination of cysteine/homocysteine (cyan fluorescence) and glutathione (blue fluorescence) via specific chemodosimetric interactions.
Conclusions:
- A novel CT hydrogel system based on supramolecular assembly was successfully developed.
- The hydrogel exhibits stimuli-responsive behavior and unique self-assembled structures.
- The CT hydrogel serves as an effective platform for discriminating biogenic thiols based on distinct fluorescence outputs.
