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The relationship between intestinal goblet cells and the immune response
1College of Animal Veterinary Medicine, Northwest A & F University, Yangling 712100, Shaanxi, People's Republic of China.
Bioscience Reports
|October 5, 2020
Summary
Goblet cells secrete mucin, forming a protective mucus layer that prevents pathogen invasion and aids immune responses. This review explores their barrier function, antigen transport, and immune system interactions.
Area of Science:
- Gastroenterology
- Immunology
- Cell Biology
Background:
- Goblet cells (GCs) are crucial single-cell glands in the intestinal epithelium.
- They secrete mucin, forming a vital mucus layer for protection.
- GCs also participate in immune surveillance via endocytosis and antigen passage.
Purpose of the Study:
- To review the barrier functions of the mucus layer produced by goblet cells.
- To examine the role of goblet cells in pathogen resistance and immune response.
- To explore luminal substance delivery mechanisms, such as goblet cell-associated antigen passages (GAPs).
Main Methods:
- Literature review of studies on goblet cell function.
- Analysis of research on mucus layer properties and barrier mechanisms.
- Synthesis of findings on goblet cell interactions with microorganisms and the immune system.
Main Results:
- The mucus layer provides a physical barrier against pathogenic microorganisms.
- Goblet cells facilitate antigen sampling and presentation to underlying immune cells.
- Immuno-regulatory factors influence goblet cell differentiation, maturation, and mucin secretion.
Conclusions:
- Goblet cells and their secreted mucin are essential for intestinal homeostasis and defense.
- GCs play a dual role in barrier function and immune modulation.
- Understanding GCs offers insights into gut health and disease management.
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