Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Errors: Detection and Minimization01:12

Types of Errors: Detection and Minimization

8.2K
Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...
8.2K
Detection of Gross Error: The Q Test01:00

Detection of Gross Error: The Q Test

6.7K
When one or more data points appear far from the rest of the data, there is a need to determine whether they are outliers and whether they should be eliminated from the data set to ensure an accurate representation of the measured value. In many cases, outliers arise from gross errors (or human errors) and do not accurately reflect the underlying phenomenon. In some cases, however, these apparent outliers reflect true phenomenological differences. In these cases, we can use statistical methods...
6.7K
Improving Translational Accuracy02:07

Improving Translational Accuracy

13.2K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
13.2K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.4K
3.4K
Leaky Scanning02:28

Leaky Scanning

5.5K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.5K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

11.4K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paradoxical inhibition of autonomic output following cortical suppression: When inhibiting an inhibitor results in more (not less) inhibition.

Neuropsychologia·2026
Same author

Cost-effectiveness of radiologist reading of chest CT scans assisted by software with artificial intelligence-derived algorithms for the detection and analysis of lung nodules.

BJR artificial intelligence·2026
Same author

Methods and mechanisms for measuring and monitoring outcomes from newborn bloodspot screening: a scoping review.

Health technology assessment (Winchester, England)·2026
Same author

Evaluating whole genome sequencing for rare diseases in newborn screening: evidence synthesis from a series of systematic reviews.

Health technology assessment (Winchester, England)·2025
Same author

Challenges in evaluating whole genome sequencing for newborn screening: series of systematic reviews and roadmap for evidence generation for policy advisers.

BMJ medicine·2025
Same author

Intrinsic motivation and false feedback reduce the low prevalence effect.

Cognitive research: principles and implications·2025

Related Experiment Video

Updated: Dec 6, 2025

Eye-tracking to Distinguish Comprehension-based and Oculomotor-based Regressive Eye Movements During Reading
05:54

Eye-tracking to Distinguish Comprehension-based and Oculomotor-based Regressive Eye Movements During Reading

Published on: October 18, 2018

6.5K

Double reading reduces miss errors in low prevalence search.

Melina A Kunar1, Derrick G Watson1, Sian Taylor-Phillips2

  • 1Department of Psychology, The University of Warwick.

Journal of Experimental Psychology. Applied
|October 5, 2020
PubMed
Summary
This summary is machine-generated.

Double reading, where two people review medical images, significantly reduces missed diagnoses in rare conditions. This paired approach improves accuracy in tasks like mammography screening.

More Related Videos

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.4K
Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.1K

Related Experiment Videos

Last Updated: Dec 6, 2025

Eye-tracking to Distinguish Comprehension-based and Oculomotor-based Regressive Eye Movements During Reading
05:54

Eye-tracking to Distinguish Comprehension-based and Oculomotor-based Regressive Eye Movements During Reading

Published on: October 18, 2018

6.5K
Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.4K
Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.1K

Area of Science:

  • Cognitive psychology
  • Medical imaging analysis
  • Human factors in diagnostics

Background:

  • Rarely occurring targets are frequently missed in visual search tasks.
  • This is a critical issue in medical screening, such as mammography, for detecting infrequent cancers.
  • Current single-reader methods may not be optimal for low-prevalence diagnostic tasks.

Purpose of the Study:

  • To investigate if a "double reading" procedure, involving paired search, reduces miss errors compared to single-person search.
  • To determine the impact of shared versus independent reading environments on the effectiveness of double reading.
  • To explore how reading order influences miss errors in paired search scenarios.

Main Methods:

  • Experiment 1: Participants searched for masses in laboratory mammograms, either together in the same room or independently in separate rooms.
  • Experiment 2: Manipulated the order in which paired participants reviewed mammograms (same or different orders).
  • Compared miss error rates between single-reading and double-reading conditions across different environmental setups.

Main Results:

  • Double reading significantly reduced miss errors compared to single reading.
  • No significant effect of reading order on miss errors was observed.
  • The mechanism of improvement in double reading varied by environment: increased sensitivity in shared rooms, altered response bias in separate rooms.

Conclusions:

  • Paired "double reading" is an effective strategy to reduce miss errors in low-prevalence visual search tasks, like mammography.
  • The benefits of double reading are influenced by the reading environment, affecting sensitivity and response bias differently.
  • This has direct implications for improving diagnostic accuracy in medical screening programs.