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Stem Cell Therapy for Neurogenic Bladder Dysfunction in Rodent Models: A Systematic Review.

Hanieh Salehi-Pourmehr1, Sakineh Hajebrahimi1,2, Reza Rahbarghazi3

  • 1Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.

International Neurourology Journal
|October 6, 2020
PubMed
Summary

Stem cell (SC) therapy shows promise for neurogenic bladder dysfunction (NGB) after spinal cord injury (SCI) in rodent models, improving bladder function. Further research is needed for other neurological conditions.

Keywords:
Neurogenic bladderRodent modelsStem cell therapySystematic review

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Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Urology

Background:

  • Neurogenic bladder dysfunction (NGB) significantly impacts quality of life.
  • Preclinical studies are crucial for understanding NGB management.
  • Spinal cord injury (SCI), multiple sclerosis (MS), Parkinson disease (PD), and stroke are key neurological conditions causing NGB.

Purpose of the Study:

  • To investigate the efficacy of stem cell (SC) therapy in restoring bladder function following neurological damage in rodent models.
  • To review preclinical research on SC therapy for NGB caused by SCI, MS, PD, and stroke.

Main Methods:

  • A systematic review and meta-analysis of studies published up to June 2019.
  • Inclusion of 20 studies from 1,189 relevant publications.
  • Focus on rodent models of SCI, PD, stroke, and MS, with urodynamic analysis.

Main Results:

  • Commonly used SC sources include neural progenitor cells and mesenchymal stem cells.
  • Significant improvements in micturition pressure were observed in SCI models post-SC transplantation.
  • Bladder capacity and residual urine volume improved in transaction SCI models; nonvoiding contractions recovered in contusion SCI models.

Conclusions:

  • Stem cell therapy demonstrates partial bladder recovery in SCI models.
  • Additional research is required to elucidate the mechanisms of bladder recovery in other neurological diseases.