One-step Implantation of a 3D Neural Microelectrode Array.

Area of Science:

• Neurosurgery
• Biomedical Engineering
• Neuroscience

Background:

• Peripheral nerve interfaces are crucial for neuroprosthetics and research.
• Accurate and safe implantation of microelectrode arrays into flexible nerves remains a challenge.
• Existing methods may lack the precision and stability required for chronic implantation.

Purpose of the Study:

• To introduce the NEIT 2 (Nerve Electrode Insertion Tool), a device designed for precise 3D microelectrode array implantation into peripheral nerves.
• To evaluate the efficacy and safety of the NEIT 2 in animal models.
• To demonstrate the capability for chronic neural signal recording post-implantation.

Main Methods:

• Development and utilization of a 3D printed prototype of the NEIT 2.
• Employing an elastomer nerve holder for stable nerve targeting and fixation.
• Performing surgical implantation of microelectrode arrays into rat sciatic nerves.
• Recording neural signals through chronically implanted electrodes.

Main Results:

• Successful implantation of 3D microelectrode arrays into the sciatic nerves of rats.
• Demonstration of stable nerve targeting and safe electrode insertion using the NEIT 2.
• Acquisition of neural signals via chronically implanted electrodes, validating device functionality.
• The nerve containment assembly was successfully created in one step.

Conclusions:

• The NEIT 2 is an effective neurosurgical device for implanting 3D microelectrode arrays into peripheral nerves.
• The device enables stable nerve targeting and safe implantation, facilitating chronic neural recordings.
• This technology holds promise for advancing peripheral nerve interface applications in research and neuroprosthetics.