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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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A Compact Optical Pressure Measurement System for Acquiring Intraocular Pressure and Ocular Pulse.

Alex Phan, Kevin Joslin, Phuong Truong

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |October 6, 2020
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    Summary

    Researchers developed a miniaturized, implantable intraocular pressure sensor to measure ocular pulse. This novel sensor, based on interferometry, accurately tracks eye pressure fluctuations for better glaucoma management.

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    Area of Science:

    • Ophthalmology
    • Biomedical Engineering
    • Medical Devices

    Background:

    • Accurate intraocular pressure (IOP) monitoring is crucial for glaucoma management.
    • IOP fluctuates daily and with heart rate, a phenomenon known as the ocular pulse.
    • Current monitoring methods may lack the precision needed for real-time therapeutic adjustments.

    Purpose of the Study:

    • To report the measurement of the ocular pulse profile using a novel miniaturized IOP sensor.
    • To assess the sensor's accuracy and feasibility in an animal model.
    • To demonstrate a new method for continuous IOP monitoring.

    Main Methods:

    • A miniaturized, passive interferometric IOP sensor was implanted in a New Zealand White rabbit eye.
    • The sensor measures ocular pulse variations without requiring an internal power source.
    • Ocular pulse profiles were recorded using both a DSLR and a smartphone reader.

    Main Results:

    • The ocular pulse profile was successfully measured using the implanted sensor.
    • Measurements achieved an accuracy of +/- 0.15 mmHg.
    • The sensor effectively captured pressure variations up to 5 Hz.

    Conclusions:

    • The developed interferometric IOP sensor enables accurate measurement of ocular pulse.
    • This technology offers a promising approach for continuous and precise IOP monitoring in glaucoma patients.
    • The use of external readers like smartphones suggests potential for user-friendly clinical application.