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Weekly psoriasis therapy using intralesional fluorouracil.

D L Pearlman, B Youngberg, C Engelhard

Journal of the American Academy of Dermatology

|July 1, 1987

Summary

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Weekly intralesional fluorouracil injections effectively treated psoriasis lesions, showing significant clearing within weeks. This method offers a well-tolerated, long-term therapeutic option for psoriasis management.

Area of Science:

Dermatology
Pharmacology

Background:

Psoriasis is a chronic inflammatory skin condition.
Topical treatments for psoriasis can have limitations in efficacy and speed of response.

Purpose of the Study:

To evaluate the efficacy and safety of weekly intralesional fluorouracil for treating psoriatic papules and plaques.

Main Methods:

Eleven patients received weekly intralesional injections of fluorouracil (50 mg/ml) into psoriatic lesions.
Control lesions were left untreated for comparison.
Lesion response and side effects were monitored over time.

Main Results:

Treated lesions showed an average of 4.2 cm2 clearing, while control lesions showed no improvement.
Earliest signs of improvement were observed within 2 weeks, with maximum clearing around 4 weeks.

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Four out of nine patients with a favorable response remained in remission at 3-month follow-up.

Adverse effects were localized, including hyperpigmentation and mild to moderate irritation; no systemic toxicity was reported.

Conclusions:

Weekly intralesional fluorouracil is an effective and well-tolerated treatment for psoriasis.
Intralesional administration offers faster therapeutic response compared to topical application.
The treatment provides localized efficacy with potential for long-term benefit.