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Updated: Dec 6, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Relationship of miRNA-146a to systemic lupus erythematosus: A PRISMA-compliant meta-analysis

Yihua Fan1,2, Yue Ji2,3, Xuyan Wang4

  • 1Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine.

Medicine
|October 6, 2020
PubMed
Abstract

Insights

This meta-analysis found that miRNA-146a expression is linked to an increased risk of systemic lupus erythematosus (SLE). Despite study limitations, miRNA-146a shows potential as a diagnostic marker for SLE.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with complex pathogenesis.
  • MicroRNA-146a (miRNA-146a) has been implicated in SLE, but previous studies yielded conflicting results.
  • A comprehensive meta-analysis is needed to clarify the role of miRNA-146a in SLE.

Purpose of the Study:

  • To systematically evaluate the association between miRNA-146a expression levels and the risk of developing SLE.
  • To synthesize evidence from existing studies to provide a more definitive conclusion on miRNA-146a's role in SLE pathogenesis.

Main Methods:

  • A meta-analysis was conducted on studies published up to August 31, 2019, searching multiple databases.
  • Data extraction and quality assessment were performed independently by two investigators.
  • Statistical analyses included standard mean difference (SMD) calculations and Trial Sequence Analysis (TSA) for robustness.

Main Results:

  • Six studies with 151 SLE patients and 132 controls were included.
  • A significant association was found between miRNA-146a expression and SLE risk (SMD = -1.21, P = .015).
  • Stratified analyses indicated a higher risk in Asian and Caucasian populations; serum levels also differed significantly. TSA suggested reliable conclusions despite not meeting the required information size.

Conclusions:

  • miRNA-146a expression is significantly associated with an increased risk of SLE.
  • miRNA-146a is a potential biomarker for SLE diagnosis.
  • Further research is warranted due to study limitations and sensitivity analysis indicating instability.

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