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Updated: Dec 6, 2025
05:20
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
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Bone and bone marrow involvement in neuroblastoma: A case report.
Can Huang1, Shayi Jiang, Xuelian Liao
1Department of Hematology and Oncology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Medicine
|October 6, 2020
Summary
This study reports a rare case of neuroblastoma (NB) presenting solely with bone lesions and no solid mass. Standard treatments showed limited efficacy, highlighting the need for novel therapeutic strategies for this rare neuroblastoma subtype.
Area of Science:
- Pediatric Oncology
- Cancer Biology
- Medical Imaging
Background:
- Neuroblastoma (NB) is a heterogeneous cancer originating in the sympathetic nervous system.
- NB typically presents with solid tumors, making cases with only bone marrow and bone involvement rare.
Observation:
- A 2-year-old girl experienced recurrent fevers and leg pain.
- Bone marrow biopsy confirmed NB infiltration; MRI revealed vertebral and femoral lesions without any detectable solid mass on CT scans.
Findings:
- The patient initially responded to standard high-risk NB chemotherapy.
- Recurrence was confirmed via bone marrow examination two years after initial treatment.
Implications:
- Conventional chemotherapy and radiotherapy offer limited improvement for this rare NB variant.
- New treatment strategies are essential for improving outcomes in patients with bone-only neuroblastoma.
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