The molecular mechanisms of celecoxib in tumor development
Bin Wen1, Ying-Ting Wei, Lan-Lan Mu
1Department of Gastroenterology, Affiliated Hospital to Zunyi Medical University, Zunyi, Guizhou Province, China.
Background:
Clinical studies have shown that celecoxib can significantly inhibit the development of tumors, and basic experiments and in vitro experiments also provide a certain basis, but it is not clear how celecoxib inhibits tumor development in detail.
Methods:
A literature search of all major academic databases was conducted (PubMed, China National Knowledge Internet (CNKI), Wan-fang, China Science and Technology Journal Database (VIP), including the main research on the mechanisms of celecoxib on tumors.
Results:
Celecoxib can intervene in tumor development and reduce the formation of drug resistance through multiple molecular mechanisms.
Conclusion:
Celecoxib mainly regulates the proliferation, migration, and invasion of tumor cells by inhibiting the cyclooxygenases-2/prostaglandin E2 signal axis and thereby inhibiting the phosphorylation of nuclear factor-κ-gene binding, Akt, signal transducer and activator of transcription and the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. Meanwhile, it was found that celecoxib could promote the apoptosis of tumor cells by enhancing mitochondrial oxidation, activating mitochondrial apoptosis process, promoting endoplasmic reticulum stress process, and autophagy. Celecoxib can also reduce the occurrence of drug resistance by increasing the sensitivity of cancer cells to chemotherapy drugs.
Insights
Celecoxib inhibits tumor development and drug resistance through multiple molecular mechanisms. It targets key signaling pathways, promotes cancer cell apoptosis, and enhances chemotherapy sensitivity.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Clinical studies indicate celecoxib inhibits tumor development.
- Preclinical and in vitro data support celecoxib's anti-tumor effects.
- Detailed mechanisms of celecoxib's action on tumors remain unclear.
Purpose of the Study:
- To elucidate the detailed molecular mechanisms by which celecoxib inhibits tumor development.
- To review the multifaceted roles of celecoxib in cancer progression and drug resistance.
Main Methods:
- Comprehensive literature search across major academic databases (PubMed, CNKI, Wan-fang, VIP).
- Inclusion of studies focusing on the mechanisms of celecoxib in tumor development and resistance.
Main Results:
- Celecoxib intervenes in tumor progression via multiple molecular pathways.
- It reduces the development of drug resistance.
- Celecoxib impacts tumor cell proliferation, migration, and invasion.
Conclusions:
- Celecoxib inhibits the cyclooxygenase-2/prostaglandin E2 pathway, affecting downstream signaling (NF-κB, Akt, STAT).
- It modulates matrix metalloproteinase expression (MMP-2, MMP-9).
- Celecoxib promotes tumor cell apoptosis through mitochondrial and endoplasmic reticulum stress pathways, and enhances autophagy, while increasing sensitivity to chemotherapy.
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