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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
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Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications.

Sheila Maiz-Fernández1,2, Leyre Pérez-Álvarez1,2, Leire Ruiz-Rubio1,2

  • 1BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain.

Polymers
|October 6, 2020
PubMed
Summary

In situ hydrogels, particularly those from natural polysaccharides, offer non-invasive, adaptable platforms for tissue regeneration. Their self-healing properties enhance integrity and potential for personalized medicine.

Keywords:
dynamic bondsin situ hydrogelsinjectabilitypolysaccharideself-healingtissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Traditional hydrogels necessitate invasive surgical implantation, limiting personalized medicine approaches.
  • In situ hydrogels provide non-invasive, localized delivery and adaptable integration for various defect sites.
  • Natural polysaccharide-based hydrogels are gaining traction due to biocompatibility, biodegradability, and self-healing capabilities.

Purpose of the Study:

  • To review the mechanisms of self-healing in hydrogels.
  • To present recent advancements in in situ self-healing hydrogels.
  • To explore the applications of these materials in tissue regeneration.

Main Methods:

  • Literature review focusing on self-healing mechanisms in hydrogels.
  • Analysis of recent research on in situ self-healing hydrogel development.
  • Examination of studies on tissue regeneration applications.

Main Results:

  • In situ hydrogels offer significant advantages over traditional hydrogels, including non-invasive implantation and adaptability.
  • Self-healing in hydrogels is achieved through physical interactions or dynamic covalent bonds, enabling integrity maintenance after damage.
  • Natural polysaccharides are key components in advanced self-healing hydrogels.

Conclusions:

  • In situ self-healing hydrogels, especially those derived from natural polysaccharides, represent a promising frontier in regenerative medicine.
  • Their adaptable and non-invasive nature, coupled with self-repair capabilities, facilitates personalized therapeutic strategies.
  • Further research into these advanced materials holds significant potential for diverse tissue regeneration applications.