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Same-side insufficiency fractures of the tibia and femur after denosumab discontinuation: a case report
Hidefumi Koiwai1, Mikio Kamimura2, Yukio Nakamura3
1Koiwai Orthopedic Clinic, Komoro, Japan.
Abstract:
Osteoporosis (OP) is a common disease in the elderly that causes bone fractures and increases mortality. Denosumab (DMAB) is one of several medications to treat OP. DMAB not only reduces the risk of fractures, but also improves the quality of life. However, an increase in the risk of multiple vertebral fractures has been reported after DMAB discontinuation. We described the rare case of a 71-year-old woman with severe OP who experienced same-side insufficiency fractures of the tibia and femur at 18 months after DMAB discontinuation. Careful monitoring for both vertebral and lower limb fragility fractures is advised after DMAB cessation.
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