Related Experiment Video
Updated: Dec 6, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
A Case of Quinacrine-induced Psychosis: Case Report
Anangamanjari Pedapudi1, Jonathan Stewart1, Ankita Patel2
1Department of Psychiatry and Behavioral Neurosciences, University of South Florida Morsani College of Medicine, Tampa, FL33612, United States.
Background:
Quinacrine is an older antimalarial drug that remains in use for a variety of illnesses including treatment-resistant giardiasis.
Case Presentation:
We report a patient with no prior psychiatric history who developed mild, prodromal psychiatric symptoms when treated with quinacrine for treatment-resistant giardiasis. Symptoms resolved when the drug was stopped, recurred with greater severity (requiring involuntary psychiatric hospitalization) when restarted and promptly resolved again when the drug was finally stopped.
Conclusion:
Although quinacrine remains in use today, providers may be unaware of its potential for serious neuropsychiatric toxicity.
Related Concept Videos
Psychosis and Antipsychotic Drugs: Overview
Mania and Antimanic Drugs: Overview
Psychosis: Goals of Pharmacotherapy
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Antipsychotic Drugs: Typical and Atypical Agents

