Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Elastin is Responsible for Tissue Elasticity

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Grafts in tendon repair.

Materials today. Bio·2026

Same author

Bioprinting vascularized skin analogs: a stepwise approach.

Burns & trauma·2025

Same author

Sheep femoral artery occlusion is well tolerated and does not result in ischemia.

Animal models and experimental medicine·2025

Same author

Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models.

Science translational medicine·2025

Same author

Corrigendum to "Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing" [Biomaterials 139 (2017), 18080].

Biomaterials·2024

Same author

Perspectives on Recent Developments and Directions in Tissue Engineering and Regenerative Medicine.

Tissue engineering. Part A·2024

Search research articles

Related Experiment Video

Updated: Dec 6, 2025

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

Fabricating Organized Elastin in Vascular Grafts.

Ziyu Wang¹, Linyang Liu¹, Suzanne M Mithieux¹

¹Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.

Trends in Biotechnology

|October 6, 2020

Summary

Biodegradable vascular grafts can regenerate into neoarteries. However, the lack of elastin in current grafts hinders long-term success, necessitating elastin incorporation for improved performance.

Keywords:

elastic fiber elastin elastogenesis tropoelastin vascular graft vascular tissue engineering

More Related Videos

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Published on: June 27, 2018

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Related Experiment Videos

Last Updated: Dec 6, 2025

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Published on: June 27, 2018

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Area of Science:

Biomaterials Science
Regenerative Medicine
Vascular Surgery

Background:

Synthetic vascular grafts offer a promising approach for repairing damaged arteries, enabling regeneration into neoarteries.
Elastin, a critical component of the arterial extracellular matrix, is notably absent in many current vascular grafts.
This deficiency in elastin is a primary reason for the long-term failure of synthetic vascular grafts.

Purpose of the Study:

To highlight the crucial role of elastin in vascular graft success.
To review current advancements in vascular tissue engineering focused on elastin.
To explore strategies for incorporating elastin into vascular grafts to improve in vivo performance and longevity.

Main Methods:

Literature review of current research in vascular tissue engineering.
Analysis of the functional importance of elastin in native arteries.
Identification of strategies for de novo elastin production or biomaterial incorporation.

Main Results:

The absence of elastin in synthetic vascular grafts is a significant barrier to their long-term functionality.
Advances in tissue engineering are exploring methods for creating or integrating elastin into grafts.
These approaches aim to enhance graft remodeling and integration with host tissue.

Conclusions:

Incorporating elastin or elastin-based biomaterials into synthetic vascular grafts is essential for achieving successful and durable neoartery formation.
Future research should focus on developing effective methods for elastin integration to overcome current limitations in vascular graft technology.