Blastomogenic effect of benzene

This paper presents a critical review more than 100 references on the possible leukomogenic (blastomogenic) effects of benzene, based upon clinical, epidemiological and experimental dates. The authors came to conclusion that there exist reliable clinical and epidemiological evidences, concerning increased leukomogenic risk on working place with high benzene concentrations in past years (tens and even hundreds of ppm). Most epidemiological studies, indicate now that this risk is also elevated in more favourable working conditions, although practical valuable dose-effect relationship between benzene concentrations and rate of leukomogenic risks is still unknown. Results of experimental investigations on problem of leukomogenic effects of benzene are contradictory. It was stated recently that there is a lack of adequate experimental models of benzene blastomogenesis. Taking into consideration increasing economic significance of benzene and existence of large contingents of workers dealing with benzene, it is necessary to continue appropriate experimental and epidemiological investigations.