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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

756
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
756
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

199
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
199
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

685
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
685
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

211
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
211
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

194
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
194

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Trends in the incidence and surgical treatment of hepatocellular carcinoma in Ontario.

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Murine Full-thickness Skin Transplantation
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Recent developments and ongoing trials in transplant oncology.

Beat Moeckli1, Tommy Ivanics2, Marco Claasen2,3

  • 1Department of Visceral and Transplantation Surgery, University of Geneva Hospitals, Geneva, Switzerland.

Liver International : Official Journal of the International Association for the Study of the Liver
|October 6, 2020
PubMed
Summary

Liver transplantation is increasingly used for cancer treatment, offering a cure for many liver tumors. Ongoing research aims to improve patient selection, recurrence management, and neoadjuvant therapies for better outcomes in transplant oncology.

Keywords:
cholangiocarcinomacolorectal liver metastasishepatocellular carcinomaliver transplantationneuroendocrine liver metastasistransplant oncology

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Area of Science:

  • Transplant oncology
  • Hepatobiliary surgery
  • Gastroenterology

Background:

  • Liver transplantation is a curative option for select liver tumors.
  • The Milan criteria have guided patient selection for two decades.
  • Transplant oncology has seen significant advancements, increasing oncological indications for liver transplants.

Purpose of the Study:

  • To review the current status of liver transplantation for oncological indications.
  • To summarize ongoing research and future trends in transplant oncology.
  • To discuss challenges in patient selection, recurrence, and neoadjuvant treatments.

Main Methods:

  • Review of current literature on liver transplantation for liver tumors.
  • Analysis of advancements in patient selection and treatment protocols.
  • Exploration of emerging research in diagnostic modalities and therapies.

Main Results:

  • Liver transplantation is a viable treatment for hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastasis, and neuroendocrine tumors.
  • Challenges include adequate patient selection, post-transplant recurrence, and neoadjuvant protocols.
  • Active clinical trials are investigating new diagnostics, treatments, and surgical techniques.

Conclusions:

  • Liver transplantation is a crucial tool in managing liver tumors.
  • Continued research is essential to refine selection criteria and treatment strategies.
  • Future advancements will enhance the efficacy and application of liver transplantation in oncology.