Emerging therapeutic targets for neuroblastoma

Area of Science:

• Pediatric oncology
• Cancer biology
• Molecular therapeutics

Background:

• Neuroblastoma (NB) is a primary infant cancer, causing significant pediatric mortality.
• High-risk neuroblastoma (HR-NB) presents poor prognosis despite intensive treatments.
• Novel therapeutic strategies are urgently needed for HR-NB cure and improved survival.

Purpose of the Study:

• To review recent studies (2017-2020) on NB evolution.
• To identify novel and effective therapeutic targets for HR-NB.
• To categorize promising therapeutic strategies for HR-NB.

Main Methods:

• Selective review of recent scientific literature (2017-2020).
• Categorization of therapeutic targets and strategies for HR-NB.
• Analysis of emerging evidence for novel and integrative approaches.

Main Results:

• Identified key therapeutic targets: lncRNAs, microRNAs, immunotherapy, epithelial-to-mesenchymal transition, and cancer stem cells.
• Highlighted the potential of combination therapies and drug repurposing.
• Emphasized the need for efficient drug delivery systems for functional targets.

Conclusions:

• A single-target approach is unlikely to cure HR-NB.
• Integrated therapeutic strategies and efficient drug delivery are essential for advancing HR-NB clinical therapy.
• Promising novel targets and improved treatment strategies are evolving for HR-NB.