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Infant Pyogenic Liver Abscess Complicated With Autoimmune Neutropenia: Two Cases

Shogo Otake1, Rin Tamashiro1, Naoya Morisada2

  • 1From the Division of Infectious Disease.

The Pediatric Infectious Disease Journal
|October 6, 2020
PubMed

Insights

Autoimmune neutropenia (AIN) can lead to severe infections like pyogenic liver abscess in infants. Early AIN diagnosis is crucial for managing childhood liver abscesses effectively.

Area of Science:

  • Pediatric Hematology
  • Infectious Diseases
  • Immunology

Background:

  • Autoimmune neutropenia (AIN) is characterized by low neutrophil counts, often leading to recurrent infections.
  • While typically causing mild infections, severe complications can occur.
  • The association between AIN and pyogenic liver abscesses in infants is not widely recognized.

Observation:

  • Two cases of infants presenting with pyogenic liver abscess complicated by AIN are described.
  • These infants experienced severe bacterial infections despite varying degrees of neutropenia.

Findings:

  • Pyogenic liver abscess can be a presenting complication of autoimmune neutropenia in infants.
  • Neutrophil counts in AIN patients may not always correlate directly with infection severity.

Implications:

  • Clinicians should consider AIN in the differential diagnosis of pyogenic liver abscess in children.
  • Prompt identification of AIN can guide appropriate management and prevent further complications.
  • This highlights the importance of a comprehensive etiological workup for pediatric liver abscesses.

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