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Tomato-Oleoresin Anti-Inflammatory Effect Recovers Obesity-Induced Cardiac Dysfunction by Modulating Myocardial
Artur Junio Togneri Ferron1, Fabiane Valentini Francisqueti-Ferron2, Carol Cristina Vágula de Almeida Silva2
1Medical School, Sao Paulo State University (UNESP), Botucatu, Brazil, artur.ferron@gmail.com.
Background/Aims:
Considering the importance of inflammation on obesity-related disorders pathogenesis, including cardiac dysfunction, the interest in natural anti-inflammatory therapeutic strategies has emerged. The lycopene is a carotenoid presents in tomato and red fruits that displays anti-inflammatory properties. In this sense, we will evaluate the anti-inflamma- tory effect of tomato-oleoresin supplementation on obesity- related cardiac dysfunction by modulating myocardial calcium kinetic.
Methods:
Male Wistar rats were initially randomized into 2 experimental groups: (Control, n= 20) or high sugar- fat diet (HSF, n=20) for 20 weeks. At week 20th, once detected the cardiac dysfunction (cardiac remodeling, systolic and diastolic dysfunction) by echocardiography in HSF group, animals were randomly divided to begin the treatment with tomato-oleoresin, performing 4 groups: Control (n= 10); Control + tomato tomato-oleoresin supplementation (Control + Ly, n= 10); HSF (n= 10) or HSF + tomato tomato-oleoresin supplementation (HSF + Ly, n= 10). Tomato oleoresin was mixed with maize oil equivalent to 10mg lycopene/kg body weight (BW) per day and given orally, by gavage, every morning for a 10-week period. It was analyzed cardiac inflammatory parameters by the enzyme-linked immunosorbent assay (ELISA) and in vivo (echocardiography) and in vitro (studying isolated papillary muscles from the left ventricle) cardiac function. The groups were compared by Two-Way analysis of variance (ANOVA).
Results:
The HSF diet induced cardiac dysfunction (FS(%) C: 60.4±1.3; C+Ly: 60.9±1.3; HSF: 51.7±1.3; HSF+Ly: 59.4±1.4) and inflammation (TNF-α: C:1.88±0.41; C+Ly: 1.93±1.01; HSF: 4.58±1.99; HSF+Ly: 2.03±0.55; IL-6: C:0.58±0.16; C+Ly: 0.40±0.16; HSF: 2.00±0.45; HSF+Ly: 0.53±0.26; MCP-1: C:0.31±0.08; C+Ly: 0.43±0.22; HSF: 1.54±0.32; HSF+Ly: 0.50±0.16). Tomato-oleoresin supplementation improved cardiac remodeling and dysfunction, cardiac inflammation and myocardial calcium kinetic.
Conclusion:
the anti-inflammatory effect of tomato-oleoresin supplementation treated the obesity-induced cardiac dysfunction by modulating myocardial calcium handling.
Insights
Tomato-oleoresin supplementation, rich in lycopene, combats obesity-induced cardiac dysfunction. This natural anti-inflammatory agent improves heart function by modulating myocardial calcium handling.
Area of Science:
- Cardiovascular Research
- Nutritional Science
- Inflammation Biology
Background:
- Inflammation plays a key role in obesity-related cardiac dysfunction.
- Lycopene, a carotenoid from tomatoes, exhibits anti-inflammatory properties.
- Natural anti-inflammatory strategies are of interest for treating obesity-related disorders.
Purpose of the Study:
- To evaluate the anti-inflammatory effect of tomato-oleoresin supplementation on obesity-related cardiac dysfunction.
- To investigate the modulation of myocardial calcium kinetics by tomato-oleoresin.
- To assess the impact of lycopene on cardiac remodeling and function in an obesity model.
Main Methods:
- Male Wistar rats were fed a high sugar-fat (HSF) diet or control diet.
- Cardiac dysfunction was induced and assessed using echocardiography.
- Animals received tomato-oleoresin supplementation (10mg lycopene/kg BW/day) for 10 weeks.
- Cardiac inflammatory markers were analyzed via ELISA; cardiac function was studied in isolated papillary muscles.
Main Results:
- HSF diet induced significant cardiac dysfunction and inflammation (increased TNF-α, IL-6, MCP-1).
- Tomato-oleoresin supplementation improved cardiac remodeling and systolic/diastolic function in HSF rats.
- Supplementation significantly reduced cardiac inflammatory markers and modulated myocardial calcium kinetics.
Conclusions:
- Tomato-oleoresin, via its lycopene content, exerts anti-inflammatory effects.
- Supplementation effectively treats obesity-induced cardiac dysfunction.
- The mechanism involves the modulation of myocardial calcium handling.
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