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Computed Tomography

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Related Experiment Video

Updated: Dec 6, 2025

Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors

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Published on: April 5, 2020

Digital Breast Tomosynthesis Slab Thickness: Impact on Reader Performance and Interpretation Time.

Akshat C Pujara¹, Annette I Joe¹, Stephanie K Patterson¹

¹Form the Departments of Radiology (A.C.P., A.I.J., S.K.P., C.H.N., M.N., H.P.C., M.A.H., K.E.M.) and Biostatistics (T.M.), University of Michigan Health System, 1500 E Medical Center Dr, Med Inn Building C414, Ann Arbor, MI 48109.

|October 6, 2020

Summary

A new digital breast tomosynthesis (DBT) protocol using 6-mm slabs with 3-mm overlap significantly reduced interpretation time for radiologists. This optimized DBT approach maintained similar diagnostic performance for cancer detection compared to the standard 10-mm slab protocol.

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Area of Science:

Radiology
Medical Imaging
Breast Cancer Screening

Background:

Digital breast tomosynthesis (DBT) improves cancer detection and reduces recall rates over 2D mammography.
However, DBT interpretation time is a known limitation.

Purpose of the Study:

To assess the impact of varying DBT slab thickness and overlap on radiologist performance and interpretation time.
Specifically, to evaluate a protocol without 1-mm slices.

Main Methods:

A retrospective multireader study compared a standard DBT protocol (10-mm slabs, 5-mm overlap) with an experimental protocol (6-mm slabs, 3-mm overlap).
Four radiologists interpreted 122 DBT examinations, with interpretation times recorded.
Diagnostic performance was analyzed using receiver operating characteristic (ROC) curves.

Main Results:

Diagnostic performance for malignancy detection was similar between the standard and experimental protocols (AUCs ranging from 0.83-0.94 vs 0.84-0.92).
The experimental protocol resulted in a shorter mean interpretation time for three of the four readers.
A 72% reduction in the mean number of images and mean file size was observed with the experimental protocol.

Conclusions:

A DBT reconstruction protocol using 6-mm slabs with 3-mm overlap, omitting 1-mm slices, offers comparable diagnostic performance to the standard protocol.
This optimized protocol can lead to reduced interpretation times for breast imaging radiologists.